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1blocker safari review6/16/2023 Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. Prazosin hydrochloride capsules are indicated for the treatment of hypertension, to lower blood pressure. In clinical studies in which lipid profiles were followed, there were generally no adverse changes noted between pre-and post-treatment lipid levels. Less extensive human studies suggest similar metabolism and excretion in man. Animal studies indicate that prazosin hydrochloride is extensively metabolized, primarily by demethylation and conjugation, and excreted mainly via bile and feces. Bioavailability studies have demonstrated that the total absorption relative to the drug in a 20% alcoholic solution is 90%, resulting in peak levels approximately 65% of that of the drug in solution. The drug is highly bound to plasma protein. This effect is most pronounced on the diastolic blood pressure.įollowing oral administration, human plasma concentrations reach a peak at about three hours with a plasma half-life of two to three hours. In man, blood pressure is lowered in both the supine and standing positions. In clinical studies to date, prazosin hydrochloride has not increased plasma renin activity. There is no measurable negative chronotropic effect. The results confirm that the therapeutic effect is a fall in blood pressure unaccompanied by a clinically significant change in cardiac output, heart rate, renal blood flow and glomerular filtration rate. Hemodynamic studies have been carried out in man following acute single dose administration and during the course of long term maintenance therapy. Tolerance has not been observed to develop in long term therapy. Unlike conventional alpha-blockers, the antihypertensive action of prazosin is usually not accompanied by a reflex tachycardia. The results of dog forelimb experiments demonstrate that the peripheral vasodilator effect of prazosin is confined mainly to the level of the resistance vessels (arterioles). Recent animal studies, however, have suggested that the vasodilator effect of prazosin is also related to blockade of postsynaptic alpha-adrenoceptors. Prazosin causes a decrease in total peripheral resistance and was originally thought to have a direct relaxant action on vascular smooth muscle. The exact mechanism of the hypotensive action of prazosin is unknown. The imprinting ink also contains Black Iron Oxide, Potassium Hydroxide, Shellac.įDA approved dissolution test specifications differ from USP. 1 and the 5 mg empty gelatin capsules contain FD&C Red 3 and FD&C Blue No. In addition, the 2 mg empty gelatin capsules contain FD&C Red No. The hard gelatin capsules contain gelatin and titanium dioxide. Inert ingredients in the formulations are: colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium lauryl sulfate. Each capsule, for oral administration, contains prazosin hydrochloride, USP equivalent (as the polyhydrate) to 1 mg, 2 mg or 5 mg of prazosin. It is white to tan powder, slightly soluble in water, in methanol, in dimethyl formamide, in dimethyl acetamide, very slightly soluble in alcohol, practically insoluble in isotonic saline, in chloroform and in acetone and has a molecular weight of 419.86.
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